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Skin Cancer News
Skin Cancer Breakthrough News

November 11, 2012 
Immunotargeting of tumor subpopulations in melanoma patients: A paradigm shift in therapy approaches


From : http://www.landesbioscience.com/journals/oncoimmunology/44_2012ONCOIMM0224.pdf

Several melanoma cell subpopulations with tumor-initiating and/or tumor-maintaining properties exist that maycontribute to chemoresistance and tumor recurrence after standard therapies. One of these subpopulations expresses a B-cell marker, CD20. In a small pilot trial, we showed that a subset of stage IV melanoma patients may potentially benefit
from an adjuvant treatment using the anti-CD20 antibody rituximab.

  <READ MORE>



 

November 11, 2012 
Merck Presents Early-Stage Interim Data for MK-3475, an Investigational Therapy for the Treatment of Advanced Melanoma

  From www.BusinessWire.com

http://www.businesswire.com/news/home/20121111005025/en/Merck-Presents-Early-Stage-Interim-Data-MK-3475-Investigational

Data has so far been obtained for 85 of the 132 patients enrolled in the study. Of those patients, a total of 43 patients (51 percent) showed an objective anti-tumor response, and of those, 8 patients (9 percent) showed a complete response at or after the 12-week assessment. Notably, of the 27 patients who had previously been treated with ipilimumab monotherapy, the current standard of care for late-stage melanoma, 11 patients (41 percent) showed an objective anti-tumor response to MK-3475 monotherapy; none of those patients showed a complete response.

  <READ MORE>

 

Aug 26, 2008
Blood Pressure Drugs Linked to Protection Against Non-Melanoma Skin Cancer

  By Judith Groch, Contributing Writ, MedPage Today

PROVIDENCE, R.I., Aug. 26 -- Two classes of commonly used hypertension agents have been associated with a reduced risk of non-melanoma skin cancers in older U.S. veterans.   <READ MORE>

 

July 10, 2008
Peg-Interferon Slows Melanoma Recurrence

  By Michael Smith, North American Correspondent, MedPage Today

ROTTERDAM, July 10 -- Adjuvant treatment with pegylated interferon alfa-2b has a significant long-lasting benefit for recurrence-free survival in resected stage III melanoma, researchers here said.   <READ MORE>

 

June 18, 2008
Metastatic Melanoma Succumbs to Investigational Immunotherapy

  By John Gever, Staff Writer, MedPage Today

SEATTLE, June 18 -- An investigational T-cell therapy obliterated all signs of disease in a man with metastatic melanoma, researchers here said.  <READ MORE>

 

Apr 21, 2008
AACR: IL-12 Level May Predict Melanoma Prognosis

  By Charles Bankhead, Staff Writer, MedPage Today

SAN DIEGO, April 21 -- An elevated level of interleukin-12 was associated with a significantly increased mortality risk in patients with Stage III melanoma with regional metastasis, according to data from a large cohort study. <READ MORE>

 

Apr 21, 2008
Melanoma More Likely in the Big Moles

  By Michael Smith, North American Correspondent, MedPage Today

NEW YORK, April 21 -- Moles with a diameter of six millimeters or less were significantly less likely to be melanoma, a computer-based study showed. <READ MORE>

 

Apr 18, 2008
AACR: Molecule Promising Against Advanced Basal Cell Carcinoma

  By Charles Bankhead, Staff Writer, MedPage Today

SAN DIEGO, April 15 -- Eight of nine patients with metastatic basal cell carcinoma had durable clinical benefit with minimal toxicity when treated with an investigational compound that inhibits signaling in the Hedgehog pathway. <READ MORE>

 

Jan 21, 2008
'Ugly Duckling' Moles May Be Melanomas

  By Judith Groch, Senior Writer, MedPage Today

NEW YORK, Jan. 21 -- An irregularly pigmented mole that looks different from other irregularly pigmented moles in the same person -- an "ugly duckling" -- is likely to be a malignant melanoma, according to a preliminary study.  <READ MORE>

 

Jan 17, 2008
Virus May Cause Aggressive Merkel Cell Skin Cancer

  By Crystal Phend, Staff Writer, MedPage Today

PITTSBURGH, Jan. 17 - The rare and often-deadly Merkel cell carcinoma may be induced by a polyomavirus, researchers here reported.  <READ MORE>

 

Oct 26, 2007
AACR-NCI-EORTC: Artificial Antibody May Help T Cells Fight Melanoma

  By Crystal Phend, Staff Writer, MedPage Today

SAN FRANCISCO, Oct. 26 -- Immunity against melanoma may turn more effective through an engineered antibody that binds cancer cells to killer T cells, said researchers here.  <READ MORE>

   

 

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